effects of space flight on the chemical constituents and anti-inflammatory activity of licorice (glycyrrhiza uralensis fisch)

نویسندگان

zhang jingze school of pharmaceutical sciences and technology, tianjin university, tianjin 300072, china.

wenyuan gao school of pharmaceutical science and technology, tianjing university, no.92 weijin road, nankai district, tianjin 300072, china

shuo yan school of pharmaceutical sciences and technology, tianjin university, tianjin 300072, china.

yaxin zhao school of pharmaceutical sciences and technology, tianjin university, tianjin 300072, china.

چکیده

licorice, the oldest chinese traditional medicine, is widely used in the treatment of human diseases. due to the deficiency of wild resource, selecting and breeding becomes a key issue to expanding the supply of licorice. spaceflight technology will become a new method for medicinal plants. the aim of this study was to investigate the effect of spaceflight on the components and anti-inflammatory activity in licorice. after flowing on a recoverable satellite for 18 days, licorice seeds were germinated and grown to maturity and the parallel ground-based seeds were also planted under the same conditions. the main components in licorice root were analyzed through hplc. the contents of two components in spaceflight groups were higher than that of the ground control ones. three acute inflammatory models including xylene-induced auricular edema, carrageenan-induced paw edema and acetic acid-induced vascular permeability were utilized to compare the anti-inflammatory activity of licorice pre and post spaceflight. the licorice extract showed the significant anti-inflammation activity. after the spaceflight, the pharmacological activity of licorice got higher than that of the ground control one. all of the models gained the tendency that the spaceflight group of species hangjinqi had the strongest activity than other groups. the research provided the scientific data for a new breeding of medicinal plant through the spaceflight and indicated that the technology of space flight may be a new effective method for the breeding and cultivation of licorice.

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منابع مشابه

Effects of Space Flight on the Chemical Constituents and Anti-Inflammatory Activity of Licorice (Glycyrrhiza uralensis Fisch)

   Licorice, the oldest Chinese traditional medicine, is widely used in the treatment of human diseases. Due to the deficiency of wild resource, selecting and breeding becomes a key issue to expanding the supply of licorice. Spaceflight technology will become a new method for medicinal plants. The aim of this study was to investigate the effect of spaceflight on the components and anti-inflamma...

متن کامل

Effects of Space Flight on the Chemical Constituents and Anti-Inflammatory Activity of Licorice (Glycyrrhiza uralensis Fisch)

   Licorice, the oldest Chinese traditional medicine, is widely used in the treatment of human diseases. Due to the deficiency of wild resource, selecting and breeding becomes a key issue to expanding the supply of licorice. Spaceflight technology will become a new method for medicinal plants. The aim of this study was to investigate the effect of spaceflight on the components and anti-inflamma...

متن کامل

Effects of Space Flight on the Chemical Constituents and Anti-Inflammatory Activity of Licorice (Glycyrrhiza uralensis Fisch)

Licorice, the oldest Chinese traditional medicine, is widely used in the treatment of human diseases. Due to the deficiency of wild resource, selecting and breeding becomes a key issue to expanding the supply of licorice. Spaceflight technology will become a new method for medicinal plants. The aim of this study was to investigate the effect of spaceflight on the components and anti-inflammator...

متن کامل

Chemical profile and anti-inflammatory activity of total flavonoids from Glycyrrhiza uralensis Fisch.

Glycyrrhiza uralensis Fisch. (G. uralensis) is one of the most widely used herbal medicines for the treatment of cough, spasms, pain, inflammation and low immunity This study was designed to enrich total flavonoids (TFF) from G. uralensis and investigate the anti-inflammatory activity of TFF. The anti-inflammatory activity was evaluated by inflammatory models of dimethylbenzene (DMB)-induced ea...

متن کامل

Chemical profile and anti-inflammatory activity of total flavonoids from Glycyrrhiza uralensis Fisch.

Glycyrrhiza uralensis Fisch. (G. uralensis) is one of the most widely used herbal medicines for the treatment of cough, spasms, pain, inflammation and low immunity This study was designed to enrich total flavonoids (TFF) from G. uralensis and investigate the anti-inflammatory activity of TFF. The anti-inflammatory activity was evaluated by inflammatory models of dimethylbenzene (DMB)-induced ea...

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The immunomodulatory activities of licorice polysaccharides (Glycyrrhiza uralensis Fisch.) in CT 26 tumor-bearing mice

BACKGROUND The increasing use of complementary and alternative medicine (CAM) has kindled the need for scientific evaluation of the mechanism of action of CAMs. Although, licorice, a common ingredient in many Traditional Chinese medicine (TCM) has attracted great attention for its antitumor and immunomodulatory activities, the mechanism of action of its polysaccharides is still unclear. Here we...

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عنوان ژورنال:
the iranian journal of pharmaceutical research

جلد ۱۱، شماره ۲، صفحات ۶۰۱-۶۰۹

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